Welcome to the portal Laura. I have grown autos twice so I am no expert but would not recommend growing photos in the same tent, total pain in the ass. Every strain is different so I don't think there is a broad brush stroke way of reading them other than autos tend not to like heavy doses of nutrients. Personally I would only do 2 in a 4x4 but I like spreading my plants out. I am interested in hearing what others say. Again, welcome!